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FDA warns of drug interactions with Plavix


November 19, 2009

The Food and Drug Administration (FDA) issued a warning on Tuesday, November 17, that patients who take the blood-thinning drug Plavix should avoid taking the acid reflux medications Prilosec and Nexium because they can interfere with Plavix’s effectiveness.

The FDA said there is not enough data yet to determine if other drugs in the same family as Nexium and Prilosec—called Proton Pump Inhibitors—also present a risk.

The FDA warning did mention nine other medications that have been shown to interfere with Plavix. Those drugs are:
  • Tagamet (generic name: cimetidine)
  • Prozac, Serafem, and Symbyax (generic name: fluoxetine)
  • Luvox (generic name: fluvoxamine)
  • Ticlid (generic name: ticlopidine)
  • Diflucan (generic name: fluconazole)
  • Nizoral (generic name: ketoconazole)
  • VFEND (generic name: voriconazole)
  • Intelence (generic name: etravirine)
  • Felbatol (generic name: felbamate)

Plavix, the second-most prescribed drug in the world, is often used for heart patients after a bypass or angioplasty to prevent the formation of blood clots. If you or a family member is taking Plavix along with one of the drugs mentioned in the FDA warning, you should talk to your doctor before making any medication change.

See FDA Warns Plavix Patients of Drug Interactions at WebMd for more details.


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